Marsha Stevenson 
A spoiler alert—yes, HGH may indeed reverse aging. It’s not only scientifically proven but now also clinically proven.
Now, we have a lot to cover, but with a minimal investment of just 15 minutes of your time, it’ll all become clear.
What is HGH?
Human Growth Hormone (HGH) is a key hormone. As its name suggests, it’s responsible for growth. From birth until adolescence, it drives the linear growth of our skeleton, tissues, and organs. However, its role extends far beyond childhood. HGH impacts almost every tissue in the body, both directly and indirectly. In adults, it plays a pivotal role in maintaining a healthy metabolism, facilitating tissue regeneration, and supporting immune function—which is central to our clinical study.
HGH and Muscle Growth
Is HGH a steroid? This is a common question, mainly because both HGH and steroids are used—and some would say abused—in sports, particularly bodybuilding. The answer is simple: no. HGH is a peptide hormone, meaning it’s made up of a unique chain of 191 amino acids. Steroids, on the other hand, belong to a different class of hormones called sterol hormones, which are derived from cholesterol and share a four-ring carbon structure.
For the sports and bodybuilding enthusiasts, here’s a deeper dive: HGH has multiple layers of effects on muscle growth. It not only increases the volume of existing muscle cells (hypertrophy) but also boosts the number of muscle cells—yes, you read that right—it creates more muscle cells (hyperplasia).
HGH for Men vs. HGH for Women
Unlike anabolic steroids, which are based on testosterone (the male hormone) and can have severe side effects for women—making them something women should avoid almost at any cost—HGH has a profound and positive impact on muscle growth without causing virilization (masculinizing effects). This makes it effective and relatively safe for both men and women. If you’re wondering where to buy high-quality HGH, look no further—Sciroxxonline— You’ll find a wide variety of trusted and reliable products tailored for both men and women to help you achieve your fitness and wellness goals.
HGH and Metabolism | HGH and Fat/Weight Loss
HGH plays a pivotal role in metabolism and interacts with various glands, such as the pancreas and thyroid. It directly increases energy expenditure, raises the basal metabolic rate, and releases fat into the bloodstream, as well as sugar from the body’s energy stores.
HGH: The Anti-Aging Holy Grail or a Dangerous Myth?
HGH secretion declines with age, which takes a toll on all the positive effects we’ve discussed. For decades, many have considered HGH the anti-aging holy grail, using it anecdotally as a silver bullet against aging. However, HGH has never been approved for therapeutic treatment of aging, and no scientific literature has fully supported these claims.
HGH achieves its effects both directly and indirectly through a cascade of other hormones it triggers in the body. The most pivotal of these is IGF-1 (Insulin-like Growth Factor 1), often called HGH’s growth mediator, as it’s responsible for many of HGH’s growth-promoting effects. Interestingly, some anti-aging approaches based on animal studies suggested that high IGF-1 levels, associated with increased HGH levels, were linked to earlier mortality and shorter lifespans in these models. This raised concerns that HGH might actually be counterproductive as an anti-aging remedy.
So, How Do We Know if HGH Really Reverses Aging?
Like any well-founded experiment, we need to define our indicators. Let me introduce you to the concept of epigenetic clocks. I’m sure most of you are familiar with the idea of chronological age vs. biological age—or, in layman’s terms, how well (or poorly) our body is functioning relative to our actual calendar age. Epigenetic clocks are indicators developed to measure our biological age.
Let’s delve a bit deeper, as this is fascinating: “Epi” in Latin means “above,” so epigenetic refers to the layer above our DNA—above our inherent genetic code. It’s clear that our body constantly interacts with our DNA, and the epigenetic realm describes how our body expresses our DNA based on various conditions and circumstances. For example, two identical twins may have nearly identical DNA, but if one maintains a healthy lifestyle while the other abuses their body, the way their epigenetic layer interacts with the “same” DNA will differ, leading to different biological ages despite identical calendar ages.
Scientists have developed various epigenetic clocks based on different factors that provide accurate indicators of biological age. The most notable of these is the GrimAge predictor, which, as you might guess, provides an accurate indication of morbidity and mortality.
How Do We Track Biological Age?
To monitor and track whether we achieve age reversal, scientists have developed a sophisticated approach with distinct clinical implications. But what tools are used?
The key clinical study is called TRIIM, which stands for Thymus Regeneration, Immunorestoration, and Insulin Mitigation. Let’s break down each term and its importance for age reversal.
The “T” and the “R”: Thymus Regeneration
The study targets the regeneration of the thymus gland. I remember in my first year of anatomy class, the professor posed a challenging question: “What is the only organ the human body loses over its lifetime?” The surprising answer is the thymus gland.
The thymus gland is a small organ in your chest, behind your breastbone. It’s super important for your immune system, especially when you’re young. Its main job is to help create and train special immune cells called T-cells, which help your body fight off infections, viruses, and even cancer.
Why the Thymus Matters:
- Immune System Training: The thymus teaches T-cells to distinguish between your body’s own cells and harmful invaders.
- Protection for Kids: It’s most active in babies and children, helping build a strong immune system early in life.
- Hormones: The thymus releases hormones that help T-cells grow and function properly.
What Happens as You Age:
As you get older, the thymus slowly shrinks and is replaced by fat. This process, called involution, starts after puberty and speeds up with age. Because of this:
- Your body produces fewer new T-cells.
- Your immune system weakens, making it harder to fight off new infections or diseases.
- Older adults are more likely to get sick or develop certain health problems.
There’s a distinct collapse of the thymus gland between the early 50s and late 60s, where active cells transform into dormant fat cells. This decline coincides with a notable decrease in immune capabilities. At very advanced ages, scans show that the thymus has practically vanished, replaced entirely by fat tissue.
Immunorestoration
Another key factor in our immune system is bone marrow function. Bone marrow is the body’s primary blood cell factory. It produces white blood cells, which are essential for the immune system, helping fight infections and diseases. It also generates red blood cells and platelets, crucial for oxygen transport and blood clotting. Essentially, bone marrow is the powerhouse of immunity, constantly supplying fresh immune cells to keep the body protected. Accordingly, the TRIIM study monitors and targets the restoration and support of bone marrow function, which manifests in improved immune function.
What Tools Did the Scientists Use? What’s the “Magic Formula”?
The main pillar of the formula is HGH (Human Growth Hormone). The scientists prescribed a daily dosage of 0.015 mg/kg of HGH, equivalent to about 1.2 mg (or 3.6 IU GH) for an average person weighing 80 kg. This dosage was based on prior observations in rodent and dog studies, where growth hormone had a profound positive effect on the thymus and immune function. However, this was the first clinical experiment to measure these effects in humans.
Now, Let’s Talk Results: What Did We Find?
The findings were nothing short of remarkable. HGH treatment led to a distinct restoration of active tissue in the thymus, as clearly demonstrated by repeated MRI scans. The scans revealed a sharp increase in active thymic tissue, accompanied by a significant reduction in dormant fat tissue. Similar rejuvenating effects were observed in bone marrow function, with imaging showing higher levels of active bone marrow tissue—a critical indicator of improved immune health.
But the benefits didn’t stop there. The study closely monitored fundamental immune factors, and the results were striking. Marked improvements were seen across the board, including enhanced anti-cancer factors, reduced inflammatory markers, and overall better blood chemistry. Importantly, some blood chemistry parameters remained stable, confirming that HGH treatment didn’t disrupt normal body functioning or cause any undesirable side effects.
One of the most intriguing findings addressed a long-standing concern: the potential link between HGH, elevated IGF-1 levels, and increased cancer risk, particularly in tissues like the prostate. Contrary to these fears, the treatment actually improved markers related to prostate health, suggesting that HGH, when administered responsibly, may not pose the risks some had feared.
A Closer Look at Epigenetic Clocks: How Do We Know Aging Was Reversed?
The study relied on four major epigenetic clocks, which are among the most critical indicators of health and life expectancy. Across all clocks and all participants, there were significant improvements. On average, over the one-year study period, participants experienced an age reversal of 1.5 biological years. When you factor in that they naturally aged one chronological year during the treatment, the therapy achieved an astonishing 2.5-year reversal in biological age.
What’s even more fascinating is how the biomarkers evolved over time. Monthly testing revealed that the most dramatic improvements in aging parameters occurred between months 9 and 12, suggesting that the longer the therapy continues, the greater the benefits. This points to a cumulative effect of HGH treatment, where sustained use leads to progressively steeper improvements.
But what happens after the treatment ends? Interestingly, some regression was observed in a few epigenetic clocks after the one-year therapy concluded, meaning there was a partial loss of the age reversal achieved during the study. However, in the most important clock—the GrimAge clock, which accurately predicts mortality—there was no regression even six months after treatment ended. This underscores the treatment’s long-term effectiveness and its potential to create lasting changes in biological age.
It’s worth noting that all participants were healthy individuals whose biological age was already lower than their chronological age at the start of the study. This suggests that the treatment is particularly effective for a healthy, post-middle-age population, making it a true anti-aging marvel for those in their prime years.
About The Author
